2-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)-4-phenylpyridazin-3(2H)-one
2011
Study of a New Compound for Pain Relief
publication
Evidence: moderate
Author Information
Author(s): Aydın Abdullah, Şüküroğlu Murat, Akkurt Mehmet, Büyükgüngör Orhan
Primary Institution: Kastamonu University
Hypothesis
The new compound C26H28FN5O3 will show higher analgesic activity compared to existing drugs.
Conclusion
The compound demonstrated higher analgesic activity but also caused gastric ulceration in test animals.
Supporting Evidence
- The compound C26H28FN5O3 showed higher analgesic activity in tests.
- It caused gastric ulceration in the animals tested.
- The study used a p-benzoquinone-induced writhing test to measure pain relief.
Takeaway
Scientists created a new medicine that helps with pain, but it can also hurt the stomach.
Methodology
The compound was synthesized and tested for analgesic activity using the p-benzoquinone-induced writhing test.
Limitations
The compound caused gastric ulceration in test animals, which limits its clinical use.
Digital Object Identifier (DOI)
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