Prognostic Factors in Tongue Cancer
Author Information
Author(s): Kantola S, Parikka M, Jokinen K, Hyrynkangs K, Soini Y, Alho O-P, Salo T
Primary Institution: Oulu University Hospital, University of Oulu
Hypothesis
The study aims to evaluate the relative importance of demographic, clinical, and histological factors in patients with squamous cell carcinoma of the mobile tongue.
Conclusion
The TNM stage is the most important prognostic factor for tongue cancer, with local spread outside the tongue indicating a poorer prognosis.
Supporting Evidence
- The TNM stage was found to be the most important prognostic factor.
- Local spread outside the tongue was related to poor prognosis.
- Older age (> 65 years) was associated with poorer prognosis in stage I–II carcinomas.
- A high malignancy score was associated with poorer prognosis in stage I–II carcinomas.
- Absence of overexpressed p53 protein was associated with poorer prognosis in stage I–II carcinomas.
- Heavy use of alcohol was significantly associated with poor disease-specific survival time in stage III–IV carcinomas.
Takeaway
Doctors looked at different factors to see how they affect survival in tongue cancer patients, and found that the stage of cancer is really important.
Methodology
Demographic and clinical factors were reviewed from patient files, and histological factors were determined from pre-treatment biopsies.
Participant Demographics
Homogeneous population-based group of patients with SCC of the mobile tongue.
Digital Object Identifier (DOI)
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