Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo
2012
Pain Relief and Anti-Inflammatory Effects of Plectranthus amboinicus
Sample size: 50
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Yung-Jia Chiu, Tai-Hung Huang, Chuan-Sung Chiu, Tsung-Chun Lu, Ya-Wen Chen, Wen-Huang Peng, Chiu-Yuan Chen
Primary Institution: China Medical University
Hypothesis
The aqueous extract from Plectranthus amboinicus has analgesic and anti-inflammatory properties.
Conclusion
The study found that Plectranthus amboinicus effectively reduces pain and inflammation in mice.
Supporting Evidence
- Plectranthus amboinicus significantly inhibited pain responses in acetic acid and formalin tests.
- The extract reduced paw edema in carrageenan-induced inflammation models.
- Treatment with the extract decreased levels of proinflammatory mediators like TNF-α and COX-2.
- Antioxidant enzyme activities increased significantly after treatment with the extract.
- The extract blocked NF-κB activation, which is linked to inflammation.
- Carvacrol was identified as a major component of the extract with potential therapeutic effects.
- The study supports traditional uses of Plectranthus amboinicus in folk medicine.
Takeaway
Plectranthus amboinicus can help reduce pain and swelling, making it useful for treating inflammation.
Methodology
The study used in vivo and in vitro models to test the effects of the aqueous extract on pain and inflammation.
Limitations
The study was conducted only on mice, and results may not directly translate to humans.
Participant Demographics
Male ICR mice, 18-22g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website