Diabetic Nephropathy and Hypertension in Rats
Author Information
Author(s): ADRIANA ZUCCOLLO, MONICA NAVARRO, ORLANDO CATANZARO
Primary Institution: pROSIVAD-CONICET, Catedra de Animales de Laboratorio, Facultad de Farmacia y Bioquimica-UBA
Hypothesis
Does the progressive increase of proteinuria and decreased urinary kallikrein excretion contribute to hypertension in diabetic rats?
Conclusion
The study found that increased urinary protein excretion and lower kallikrein secretion are likely mechanisms for diabetic hypertension.
Supporting Evidence
- Diabetic hypertensive rats showed significantly lower body weight compared to control rats.
- Urinary protein excretion increased progressively in diabetic hypertensive rats.
- Systolic blood pressure was significantly elevated in diabetic hypertensive rats compared to controls.
Takeaway
The study shows that diabetic rats with more protein in their urine tend to have higher blood pressure.
Methodology
Diabetes was induced in neonatal male rats using streptozotocin, and various parameters were measured over 15 weeks.
Participant Demographics
Neonatal male rats, 2 days old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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