Indole and 3-indolylacetonitrile inhibit spore maturation in Paenibacillus alvei
2011
Indole and 3-indolylacetonitrile inhibit spore maturation in Paenibacillus alvei
publication
Evidence: moderate
Author Information
Author(s): Kim Yong-Guy, Lee Jin-Hyung, Cho Moo Hwan, Lee Jintae
Primary Institution: School of Chemical Engineering, Yeungnam University
Hypothesis
A large quantity of extracellular indole would play a quorum sensing role in cell physiology of P. alvei.
Conclusion
Indole and plant auxin 3-indolylacetonitrile inhibit spore maturation of P. alvei and decrease its survival under environmental stresses.
Supporting Evidence
- Indole production in P. alvei is strictly controlled by catabolite repression.
- Indole inhibits the development of spore coats and cortex in P. alvei.
- 3-indolylacetonitrile dramatically decreased the heat resistance of P. alvei.
Takeaway
This study found that a substance called indole can stop certain bacteria from forming protective spores, making them more vulnerable to heat and antibiotics.
Methodology
The study measured the effects of indole and its derivatives on spore formation and survival rates of P. alvei under various conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website