Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?
2011
Cancer Stem Cells and Epithelial-to-Mesenchymal Transition: Are They Cousins or Twins?
publication
Evidence: moderate
Author Information
Author(s): Kong Dejuan, Li Yiwei, Wang Zhiwei, Sarkar Fazlul H.
Primary Institution: Karmanos Cancer Institute, Wayne State University School of Medicine
Hypothesis
Are cancer stem cells and EMT-phenotypic cells related?
Conclusion
The study suggests that EMT-phenotypic cells may share molecular characteristics with cancer stem cells, contributing to tumor aggressiveness and recurrence.
Supporting Evidence
- EMT is linked to tumor aggressiveness and metastasis.
- Cancer stem cells can lead to tumor recurrence after therapy.
- EMT-phenotypic cells share characteristics with cancer stem-like cells.
- Induction of EMT can contribute to drug resistance in tumors.
Takeaway
This study looks at how certain cancer cells can change their type and become more aggressive, which might help them survive treatments.
Digital Object Identifier (DOI)
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