Myxedema Coma: A New Look into an Old Crisis
Author Information
Author(s): Mathew Vivek, Misgar Raiz Ahmad, Ghosh Sujoy, Mukhopadhyay Pradip, Roychowdhury Pradip, Pandit Kaushik, Mukhopadhyay Satinath, Chowdhury Subhankar
Primary Institution: Institute of Post-Graduate Medical Education & Research, Calcutta, India
Hypothesis
What are the preventable precipitating factors in myxedema crisis?
Conclusion
Early medical attention in hypothyroid patients developing serious illness, especially sepsis, and ensuring continuation of thyroid supplements may prevent significant morbidity and mortality.
Supporting Evidence
- Mortality rates in myxedema crisis can be as high as 25-60% even with the best treatment.
- Sepsis is the most common precipitating factor in myxedema crisis.
- Patients with myxedema crisis often present with hypothermia, bradycardia, and altered mental status.
Takeaway
Myxedema crisis is a serious condition caused by untreated hypothyroidism, and it can be life-threatening if not treated quickly. Doctors need to act fast to help patients who show signs of this crisis.
Methodology
The study discusses clinical presentation, treatment, predictors of mortality, and controversies in managing myxedema crisis based on case series and literature review.
Potential Biases
There may be a bias due to the rarity of the condition and reliance on case reports.
Limitations
The study is based on a limited number of case reports and lacks randomized controlled trials.
Participant Demographics
The condition is more common in women and the elderly.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website