Renal Effects of Dental Amalgam in Children
Author Information
Author(s): Barregard Lars, Trachtenberg Felicia, McKinlay Sonja
Primary Institution: Sahlgrenska University Hospital and Academy
Hypothesis
Does dental amalgam exposure affect renal function in children?
Conclusion
The study found an increased prevalence of microalbuminuria in children treated with dental amalgam, suggesting a potential association that requires further investigation.
Supporting Evidence
- There were no significant differences in renal biomarkers between treatment groups.
- 10 children in the amalgam group had microalbuminuria in both years 3 and 5.
- The prevalence of microalbuminuria was higher in the amalgam group compared to the composite group.
Takeaway
This study looked at kids who got dental fillings and found that those with amalgam fillings had more cases of a kidney issue called microalbuminuria, which might be linked to the fillings.
Methodology
Children aged 6-10 with dental caries were randomized to receive either amalgam or composite fillings, and renal biomarkers were measured over 5 years.
Potential Biases
Participants and dentists were not blinded to treatment assignment, which could introduce bias.
Limitations
The study primarily focused on neuropsychological outcomes, limiting the baseline assessment of renal function.
Participant Demographics
Participants were primarily non-Hispanic white (62%), with a comparable number of boys and girls.
Statistical Information
P-Value
0.04
Confidence Interval
1.1–2.9
Statistical Significance
p = 0.04
Digital Object Identifier (DOI)
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