Common Variations in CHEK2 and Breast Cancer Risk
Author Information
Author(s): Einarsdóttir Kristjana, Humphreys Keith, Bonnard Carine, Palmgren Juni, Iles Mark M, Sjölander Arvid, Li Yuqing, Chia Kee Seng, Liu Edison T, Hall Per, Liu Jianjun, Wedrén Sara
Primary Institution: Karolinska Institutet
Hypothesis
Do common polymorphisms in the CHEK2 gene influence breast cancer risk?
Conclusion
Common polymorphisms in the CHEK2 gene do not influence postmenopausal breast cancer risk in Swedish women.
Supporting Evidence
- The study genotyped six tagSNPs in 1,577 breast cancer cases and 1,513 controls.
- Common haplotypes did not show a significant association with breast cancer risk.
- The 1100delC mutation was rare in the population studied.
Takeaway
This study looked at whether common changes in a gene called CHEK2 affect the risk of getting breast cancer. It found that they don't.
Methodology
The study analyzed 14 common SNPs in the CHEK2 gene among 1,577 breast cancer cases and 1,513 controls.
Potential Biases
Nonparticipation was related to severe disease or death, which could introduce selection bias.
Limitations
The study may not be generalizable to populations outside of Northern Europe.
Participant Demographics
The study involved postmenopausal Swedish women.
Statistical Information
Confidence Interval
95% CI, 0.99–5.15
Digital Object Identifier (DOI)
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