Ocular Changes in a Young Girl with CAPS Treated with Anakinra
Author Information
Author(s): Terrada Celine, Neven Benedicte, Boddaert Nathalie, Souied Eric H, Prieur Anne Marie, Quartier Pierre, Lehoang Phuc, Bodaghi Bahram
Primary Institution: Department of Ophthalmology, APHP, Pitie-Salpetriere Hospital, Paris, France
Hypothesis
Can interleukin-1 receptor antagonist anakinra effectively treat ocular symptoms in a young girl with cryopyrin-associated periodic syndromes?
Conclusion
The treatment with anakinra led to the resolution of all symptoms and normalization of ophthalmologic signs in the patient.
Supporting Evidence
- The patient had recurrent episodes of fever, rash, and ocular involvement before treatment.
- All symptoms related to the disease ceased within a few days of starting anakinra.
- Biologic inflammatory markers normalized after one month of treatment.
Takeaway
A young girl with a rare syndrome had her eye problems go away after taking a special medicine called anakinra.
Methodology
The patient was treated with anakinra, and her symptoms and inflammation were monitored over a follow-up period of 30 months.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
An 8-year-old Caucasian girl.
Digital Object Identifier (DOI)
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