iNOS Expression and Melanoma Metastasis
Author Information
Author(s): Tschugguel W, Pustelnik T, Lass H, Mildner M, Weninger W, Schneeberger C, Jansen B, Tschachler E, Waldhör T, Huber J C, Pehamberger H
Primary Institution: University of Vienna
Hypothesis
Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma.
Conclusion
iNOS expression is inversely related to the metastatic potential of melanoma, suggesting it may predict the development of distant metastases.
Supporting Evidence
- iNOS expression was limited to melanoma cells.
- In patients without distant metastases, iNOS+ tumor cells were 55% ± 17%.
- In patients with distant metastases, iNOS+ tumor cells were 9% ± 8%.
- The study observed patients over a period of 3 years.
Takeaway
The study found that a protein called iNOS in melanoma cells can help predict if the cancer will spread to other parts of the body.
Methodology
Immunohistochemistry and Western blotting were used to investigate iNOS expression in melanoma samples.
Participant Demographics
Patients with melanoma, including those with and without distant metastases.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website