Vitamins E and D3 Reduce Inflammation in Obese Mice
Author Information
Author(s): Fábio S. Lira, José C. Rosa, Claudio A. Cunha, Eliane B. Ribeiro, Claudia Oller do Nascimento, Lila M. Oyama, João F. Mota
Primary Institution: Universidade Federal de São Paulo, Brasil
Hypothesis
Supplementation of vitamin D3 and alpha-tocopherol (vitamin E) can reduce the proinflammatory effects of high fat diets on white adipose tissue.
Conclusion
Vitamin D3 and vitamin E supplementation in a high fat diet reduced IL-6 production in adipose tissue and adipocytes, suggesting potential as adjunctive therapy for obesity-related inflammation.
Supporting Evidence
- IL-6 levels were significantly reduced in adipose tissue of mice receiving vitamin supplementation.
- Vitamin D3 and E supplementation decreased body weight gain in mice on a high fat diet.
- The IL-6/IL-10 ratio was lower in supplemented groups compared to the high fat diet group.
Takeaway
Giving mice vitamins E and D3 while they eat a lot of fat helps lower a bad chemical in their body that makes them inflamed.
Methodology
Thirty-day-old male Swiss mice were fed a high fat diet for eight weeks, with some groups receiving vitamin D3 and E supplementation, and IL-6 and IL-10 levels were measured in adipose tissue and cell cultures.
Limitations
The study was conducted on mice, which may not fully represent human responses to vitamin supplementation.
Participant Demographics
Thirty-day-old male Swiss mice.
Statistical Information
P-Value
p<0.01 for body weight gain reduction
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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