Association between subclinical right ventricular alterations and aerobic exercise capacity in type 2 diabetes

2024

Impact of Right Heart Changes on Exercise Capacity in Type 2 Diabetes

Sample size: 406 publication 10 minutes Evidence: high

Author Information

Author(s): Dattani Abhishek, Yeo Jian L., Brady Emer M., Cowley Alice, Marsh Anna-Marie, Sian Manjit, Bilak Joanna M., Graham-Brown Matthew P.M., Singh Anvesha, Arnold Jayanth R., Adlam David, Yates Thomas, McCann Gerry P., Gulsin Gaurav S.

Primary Institution: Department of Cardiovascular Sciences, University of Leicester, and the National Institute for Health and Care Research Leicester Biomedical Research Centre, Leicester, UK

Hypothesis

This study aimed to assess subclinical right heart alterations and their contribution to aerobic exercise capacity in adults with type 2 diabetes.

Conclusion

In type 2 diabetes, markers of right ventricular remodeling are associated with aerobic exercise capacity, independent of left heart alterations.

Supporting Evidence

Participants with type 2 diabetes had lower peak oxygen consumption compared to controls.
Right ventricular end-diastolic volume was smaller in the diabetes group.
Markers of right ventricular remodeling were independently associated with exercise capacity.

Takeaway

People with type 2 diabetes have changes in the right side of their heart that can make it harder for them to exercise, even if their left side is fine.

Methodology

This was a prospective, case-control study comparing adults with and without type 2 diabetes using echocardiography and cardiopulmonary exercise testing.