CORUM in 2024: protein complexes as drug targets
Author Information
Author(s): Steinkamp Ralph, Tsitsiridis George, Brauner Barbara, Montrone Corinna, Fobo Gisela, Frishman Goar, Avram Sorin, Oprea Tudor I, Ruepp Andreas
Primary Institution: Helmholtz Zentrum München, German Research Center for Environmental Health
Hypothesis
How do drugs affect the formation and function of protein complexes?
Conclusion
The expanded CORUM 5.0 dataset significantly enhances the understanding of drug effects on protein complexes, aiding in pharmacological research.
Supporting Evidence
- The CORUM database now includes 7193 protein complexes, the largest dataset of its kind.
- 1975 instances of drug effects on protein complexes were identified from the literature.
- The dataset aims to explain variable drug responses among patients.
- CORUM 5.0 is the only database that systematically annotates the impact of drugs on protein complexes.
- Understanding drug–protein complex relationships is crucial for drug efficacy.
Takeaway
This study shows that understanding how drugs interact with protein complexes can help us figure out why some medicines work differently for different people.
Methodology
The study involved systematic investigation of drug effects on protein complexes using a dataset from DrugCentral.
Limitations
Most drug effects were characterized in cell lines or in vitro, which may not reflect in vivo interactions.
Digital Object Identifier (DOI)
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