Alternative Complement Activity in the Egg Cytosol of Amphioxus Branchiostoma belcheri: Evidence for the Defense Role of Maternal Complement Components
2009
Maternal Immunity in Amphioxus Eggs
publication
Evidence: high
Author Information
Author(s): Liang Yujun, Zhang Shicui, Wang Zhiping
Primary Institution: Department of Marine Biology, Ocean University of China
Hypothesis
Do maternal complement components in amphioxus eggs play a role in defending against pathogens?
Conclusion
The study provides evidence that maternal complement components in amphioxus eggs help protect developing embryos from microbial attacks.
Supporting Evidence
- The egg cytosol inhibited the growth of Vibrio anguillarum and Staphylococcus aureus.
- Complement components C3 and Bf were identified in the egg cytosol.
- Bacteriostatic activity was reduced by pre-incubation with anti-C3 antibody.
Takeaway
Amphioxus eggs have special proteins that help protect baby amphioxus from germs, just like how some animals pass on immunity to their babies.
Methodology
The study involved preparing egg cytosol from fertilized amphioxus eggs and testing its bacteriostatic activity against specific bacteria.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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