Resistance of Mycoplasma gallisepticum to Antibiotics in Poultry
Author Information
Author(s): Irena Gerchman, Sharon Levisohn, Inna Mikula, Lucía Manso-Silván, Inna Lysnyansky
Primary Institution: Kimron Veterinary Institute, Israel
Hypothesis
What is the mechanism behind the acquired resistance to macrolides in Mycoplasma gallisepticum strains isolated from poultry?
Conclusion
The study found that mutations in the 23S rRNA gene are linked to acquired resistance to macrolides in Mycoplasma gallisepticum.
Supporting Evidence
- 50% of the Mycoplasma gallisepticum strains tested were resistant to tylosin and tilmicosin.
- 72% of strains isolated from clinical samples since 2006 showed resistance to multiple antibiotics.
- Mutations A2058G or A2059G in the 23S rRNA gene were found in resistant strains.
Takeaway
Some germs that make chickens sick are getting stronger and can resist medicine that used to work on them. This study found out why that happens.
Methodology
The study analyzed 50 Mycoplasma gallisepticum strains for antibiotic susceptibility and performed molecular typing and sequencing.
Limitations
The study focused only on strains isolated in Israel and may not represent global trends.
Participant Demographics
Strains isolated from 15 meat-type turkey flocks, 7 turkey breeder flocks, 23 broiler breeder flocks, 4 broiler flocks, and 1 Leghorn-type breeder flock.
Digital Object Identifier (DOI)
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