Lycopene Reduces Inflammation in Macrophages Exposed to Cigarette Smoke
Author Information
Author(s): Simone Rossella E., Marco Russo, Assunta Catalano, Giovanni Monego, Kati Froehlich, Volker Boehm, Paola Palozza
Primary Institution: Institute of General Pathology, Catholic University, Rome, Italy
Hypothesis
The study investigates the role of lycopene in inhibiting IL-8 production induced by cigarette smoke in human macrophages.
Conclusion
Lycopene significantly inhibits IL-8 production and NF-kB activation in macrophages exposed to cigarette smoke.
Supporting Evidence
- Lycopene pre-treatment significantly inhibited CSE-induced IL-8 expression at both mRNA and protein levels.
- Lycopene suppressed CSE-induced NF-kB DNA binding and nuclear translocation.
- Lycopene reduced CSE-induced reactive oxygen species (ROS) production.
- Lycopene increased PPARγ levels in macrophages exposed to cigarette smoke.
Takeaway
Lycopene, a substance found in tomatoes, helps protect cells from damage caused by cigarette smoke by reducing inflammation.
Methodology
Human THP-1 macrophages were treated with cigarette smoke extract and pre-treated with lycopene to measure IL-8 production and NF-kB activation.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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