Prognostic factors related to sequelae in childhood bacterial meningitis: Data from a Greek meningitis registry

2011

Prognostic Factors in Childhood Bacterial Meningitis

Sample size: 2477 publication 10 minutes Evidence: high

Author Information

Author(s): Vasilopoulou Vasiliki A, Karanika Maria, Theodoridou Kalliopi, Katsioulis Antonios T, Theodoridou Maria N, Hadjichristodoulou Christos S

Primary Institution: University of Thessaly, Aghia Sofia Children's Hospital, University of Athens

Hypothesis

What are the independent prognostic factors for sequelae in childhood bacterial meningitis?

Conclusion

A combination of prognostic factors can help identify children at risk for severe sequelae after bacterial meningitis.

Supporting Evidence

The rate of sequelae among survivors was estimated at 3.3%.
Seizures on admission were found to be a strong predictor of sequelae.
Low CSF glucose and high CSF protein were significant prognostic factors.
Positive blood culture was identified as a new prognostic factor for sequelae.
Children presenting with certain combinations of symptoms had a higher absolute risk for sequelae.

Takeaway

This study looked at children with bacterial meningitis and found that certain signs can help doctors know which kids might have problems later.

Methodology

Data was collected from a Meningitis Registry over 32 years, analyzing clinical and laboratory parameters of children diagnosed with bacterial meningitis.