Gastroprotective Effect of Rubia cordifolia on Aspirin-Induced Ulcers
Author Information
Author(s): R. S. Deoda, Kumar Dinesh, Bhujbal S. S.
Primary Institution: Marathwada Mitra Mandal's College of Pharmacy
Hypothesis
The study investigates the gastroprotective and antioxidant activities of Rubia cordifolia against aspirin-induced gastric ulcers.
Conclusion
Rubia cordifolia shows significant gastroprotective effects, particularly through its chloroform fraction, which reduces ulcer index and enhances mucosal defense mechanisms.
Supporting Evidence
- The chloroform fraction showed significant activity at lower doses compared to the parent extract.
- Total acidity and gastric acid output were significantly reduced in the treatment groups.
- Chloroform fraction significantly increased mucin content in the stomach.
Takeaway
This study found that a plant called Rubia cordifolia can help protect the stomach from ulcers caused by aspirin, making it a potential natural remedy.
Methodology
The study used Wistar rats and evaluated the effects of methanolic extract and its fractions on gastric ulcers induced by aspirin using a pylorus-ligation model.
Limitations
The study was conducted on animal models, which may not fully represent human responses.
Participant Demographics
Wistar rats weighing between 150–225 g were used.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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