Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for kupffer cells?
2006
Effects of PPARα Agonists on Liver Cells
Sample size: 5
publication
Evidence: moderate
Author Information
Author(s): Alsarra Ibrahim A, Brockmann William G, Cunningham Michael L, Badr Mostafa Z
Primary Institution: University of Missouri-Kansas City
Hypothesis
Do PPARα agonists stimulate Kupffer cells to induce hepatocellular proliferation?
Conclusion
Kupffer cells likely do not play a significant role in the liver cell proliferation caused by PPARα agonists.
Supporting Evidence
- PFOA significantly increased liver/body weight ratios.
- Methylpalmitate blocked the hepatocellular proliferative effect of PFOA.
- Serum levels of TNFα and IL-1β did not change significantly with PFOA treatment.
Takeaway
This study looked at how certain chemicals affect liver cells and found that the cells that are supposed to help with this process might not actually be involved.
Methodology
Male Sprague-Dawley rats were treated with methylpalmitate and PFOA, and liver sections were analyzed for cell proliferation.
Participant Demographics
Male Sprague-Dawley rats, 150–200 g
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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