Prevalence of Grey Matter Pathology in Early Multiple Sclerosis
Author Information
Author(s): Crespy Lydie, Zaaraoui Wafaa, Lemaire Mathias, Rico Audrey, Faivre Anthony, Reuter Françoise, Malikova Irina, Confort-Gouny Sylviane, Cozzone Patrick J., Pelletier Jean, Ranjeva Jean-Philippe, Audoin Bertrand
Primary Institution: Assistance Publique Hôpitaux de Marseille, CHU Timone, Marseille, France
Hypothesis
The study aims to assess the prevalence, distribution, and impact on disability of grey matter pathology in early multiple sclerosis.
Conclusion
The study found that grey matter pathology is common in early multiple sclerosis and is associated with irreversible disability.
Supporting Evidence
- 51% of patients showed grey matter abnormalities compared to controls.
- 37% of patients had abnormalities in the limbic cortex.
- Stepwise regression analysis showed significant association between EDSS and grey matter pathology.
Takeaway
This study looked at patients with early multiple sclerosis and found that many of them have problems in their brain's grey matter, which can make them feel worse.
Methodology
The study used magnetization transfer ratio imaging to assess grey matter pathology in 88 patients with clinically isolated syndrome and 44 healthy controls.
Limitations
The study may not fully capture the extent of grey matter pathology due to the limitations of the imaging techniques used.
Participant Demographics
Patients aged 16 to 45 with clinically isolated syndrome; 70 females and 18 males.
Statistical Information
P-Value
p=0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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