Effects of Selenium and Isoflavones on Prostate Health in Rats
Author Information
Author(s): Russell L Legg, Jessica R Tolman, Cameron T Lovinger, Edwin D Lephart, Kenneth D R Setchell, Merrill J Christensen
Primary Institution: Brigham Young University
Hypothesis
The combined effects of selenium and isoflavones will reduce androgen-regulated gene expression in rat prostate.
Conclusion
High selenium and isoflavones together may provide a greater protective effect against prostate cancer than either alone.
Supporting Evidence
- High selenium intake reduced expression of the androgen receptor.
- High isoflavone intake decreased expression of several androgen-regulated genes.
- The combination of high selenium and high isoflavones had a greater inhibitory effect on gene expression than either treatment alone.
Takeaway
Feeding rats a lot of selenium and soy can help protect their prostate from cancer better than just one of those things alone.
Methodology
Male Noble rats were fed diets with varying levels of selenium and isoflavones from conception to 200 days, and gene expression was analyzed.
Limitations
The study was conducted on rats, which may not fully represent human responses.
Participant Demographics
Male Noble rats
Statistical Information
P-Value
0.007
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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