Elevated IGFBP7 Levels in Endometriosis and Diabetic Hemodialysis Patients
Author Information
Author(s): Kutsukake Masahiko, Ishihara Ryosuke, Momose Katsutoshi, Isaka Keiichi, Itokazu Osamu, Higuma Chinatsu, Matsutani Takeshi, Matsuda Akihisa, Sasajima Koji, Hara Takahiko, Tamura Kazuhiro
Primary Institution: Tokyo University of Pharmacy and Life Sciences
Hypothesis
Do serum IGFBP7 levels reflect changes in uterine IGFBP7 expression during the menstrual cycle and in patients with various disorders?
Conclusion
The study found that IGFBP7 levels are higher in patients with endometriosis and type II diabetes, but do not reflect uterine expression during the menstrual cycle.
Supporting Evidence
- Patients with endometriosis had significantly higher serum concentrations of IGFBP7 than control subjects.
- Serum IGFBP7 levels in patients with colorectal, esophageal, or endometrial cancer were not different than normal healthy subjects.
- Hemodialysis patients with type II diabetes had significantly higher IGFBP7 levels than those without diabetes.
Takeaway
This study shows that a protein called IGFBP7 is higher in people with endometriosis and diabetes, but it doesn't change much during a woman's menstrual cycle.
Methodology
A dual-antibody sandwich ELISA was developed to measure serum IGFBP7 levels in various patient groups.
Limitations
The study did not find a correlation between serum IGFBP7 levels and uterine expression during the menstrual cycle.
Participant Demographics
62 women aged 23-45 with normal menstrual cycles, 11 women with endometriosis, 33 men undergoing hemodialysis, and 58 men with colorectal or esophageal cancers.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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