Exploring cost reduction strategies for serum free media development
2024

Cost Reduction Strategies for Serum-Free Media in Cultivated Meat Production

publication Evidence: moderate

Author Information

Author(s): Quek Jun Ping, Gaffoor Azra Anwar, Tan Yu Xuan, Tan Tessa Rui Min, Chua Yu Feng, Leong Dawn Sow Zong, Ali Alif Sufiyan, Ng Say Kong

Primary Institution: Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR)

Hypothesis

How can serum-free media (SFM) be developed more cost-effectively for cultivated meat production?

Conclusion

The review identifies various strategies to reduce the costs associated with serum-free media, which are crucial for making cultivated meat production more affordable.

Supporting Evidence

  • Serum-free media currently accounts for at least 50% of variable operating costs in cultivated meat production.
  • Advancements in serum-free media technology are essential for cultivated meat to reach price parity with conventional meat.
  • Using food-grade materials instead of pharmaceutical-grade can significantly reduce costs.
  • Genetic modifications of cell lines can potentially eliminate the need for expensive growth factors.

Takeaway

This study looks at ways to make the liquid used to grow meat cells cheaper, which is important for producing meat without animals.

Methodology

The review discusses various methodologies for developing serum-free media, including substituting fetal bovine serum with known components and using omics approaches.

Limitations

The review does not provide experimental data or specific case studies to validate the proposed strategies.

Digital Object Identifier (DOI)

10.1038/s41538-024-00352-0

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