Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
1999
Bcl-2 and p53 in Pancreatic Cancer
Sample size: 52
publication
Evidence: moderate
Author Information
Author(s): Hu Y-X, Watanabe H, Ohtsubo K, Yamaguchi Y, Ha A, Motoo Y, Okai T, Sawabu N
Primary Institution: Cancer Research Institute, Kanazawa University
Hypothesis
Does altered expression of Bcl-2 and p53 impact the progression of pancreatic carcinoma?
Conclusion
Aberrant expression of Bcl-2 and p53 is associated with more aggressive characteristics in pancreatic cancer.
Supporting Evidence
- Bcl-2 was found in 23.1% of pancreatic carcinoma cases.
- p53 was found in 63.5% of pancreatic carcinoma cases.
- There was an inverse correlation between p53 and Bcl-2 expression.
- Patients with p53-positive and Bcl-2-negative tumors had shorter survival periods.
Takeaway
This study looked at how two proteins, Bcl-2 and p53, behave in pancreatic cancer and found that their unusual patterns can make the cancer worse.
Methodology
Immunohistochemical assay was used to investigate the expression of Bcl-2 and p53 in pancreatic carcinoma cases.
Statistical Information
P-Value
P < 0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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