Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats
2012
Effects of Danggui-Shaoyao-San on Kidney Damage in Diabetic Rats
Sample size: 8
publication
10 minutes
Evidence: moderate
Author Information
Author(s): I-Min Liu, Tzeng Thing-Fong, Liou Shorong-Shii, Chang Chia Ju
Primary Institution: Tajen University
Hypothesis
Does Danggui-Shaoyao-San (DSS) improve renal injury in diabetic rats?
Conclusion
DSS treatment reduced kidney damage and improved renal function in diabetic rats.
Supporting Evidence
- DSS treatment lowered plasma glucose levels in diabetic rats.
- DSS reduced kidney hypertrophy and improved creatinine clearance.
- DSS decreased levels of advanced glycation end products in the kidneys.
- DSS enhanced antioxidant enzyme activity in the kidneys of diabetic rats.
Takeaway
This study shows that a traditional Chinese medicine called Danggui-Shaoyao-San can help protect the kidneys in diabetic rats.
Methodology
Streptozotocin-diabetic rats were treated with DSS for 12 weeks, and various renal parameters were measured.
Limitations
The study was conducted on animal models, which may not fully represent human conditions.
Participant Demographics
Male Wistar rats, aged 8–10 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website