CA9 Expression in Oesophageal Squamous Cell Carcinoma
Author Information
Author(s): Tanaka N, Kato H, Inose T, Kimura H, Faried A, Sohda M, Nakajima M, Fukai Y, Miyazaki T, Masuda N, Fukuchi M, Kuwano H
Primary Institution: Gunma University, Graduate School of Medicine
Hypothesis
The study investigates the relationship between carbonic anhydrase 9 (CA9) expression and prognosis in oesophageal squamous cell carcinoma (ESCC).
Conclusion
High expression of CA9 is associated with poor prognosis in patients with oesophageal squamous cell carcinoma.
Supporting Evidence
- 63 of the 127 primary tumour specimens showed high CA9 expression.
- High CA9 expression correlated with poor outcomes and aggressive clinicopathological parameters.
- CA9 expression was significantly associated with tumour size, depth, and metastasis.
Takeaway
This study found that a protein called CA9, which is linked to low oxygen levels in tumors, can indicate how bad the cancer is in patients with esophageal cancer.
Methodology
The study used immunohistochemistry and real-time RT–PCR to examine CA9 expression in surgical specimens from ESCC patients and cell lines.
Limitations
The study did not identify CA9 expression as an independent prognostic factor in multivariate analysis.
Participant Demographics
The study included 127 patients, with 112 males and 15 females, median age of 62 years.
Statistical Information
P-Value
P=0.0003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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