Calcium Homeostasis in Type 2 Diabetes
Author Information
Author(s): Muthuswamy Balasubramanyam, Ramalingham A. Balaji, Balakrishnan Subashini, Viswanathan Mohan
Primary Institution: Center for Biotechnology, Anna University; Madras Diabetes Research Foundation
Hypothesis
The study investigates the mechanisms of altered calcium regulation in Type 2 diabetes.
Conclusion
The study concludes that Type 2 diabetes is associated with impaired calcium homeostasis due to reduced PMCA ATPase activity and increased calcium influx.
Supporting Evidence
- Diabetic patients had significantly higher fasting plasma glucose and HbAlc levels compared to controls.
- Calcium levels were positively correlated with fasting plasma glucose and HbAlc.
- Significant reduction in PMCA ATPase activity was observed in diabetic subjects.
Takeaway
People with Type 2 diabetes have problems with how their cells handle calcium, which can affect their insulin response.
Methodology
The study used human lymphocytes from 30 Type 2 diabetes patients and 30 matched controls to measure calcium levels and transport mechanisms.
Participant Demographics
30 Type 2 diabetes patients and 30 age and weight matched control subjects.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website