No link between P53 gene variation and head and neck cancer risk
Author Information
Author(s): Hamel N, Black M J, Ghadirian P, Foulkes W D
Primary Institution: Montreal General Hospital Research Institute
Hypothesis
Is there an association between P53 codon 72 polymorphism and the risk of squamous cell carcinoma of the head and neck?
Conclusion
The study found no significant association between the P53 polymorphism and the risk of squamous cell carcinoma of the head and neck.
Supporting Evidence
- An initial report suggested a link between the P53 gene and cervical cancer, but this was not confirmed by other studies.
- Approximately 18–36% of head and neck cancers are related to HPV.
- The study found no significant excess of arginine homozygotes in cases compared to controls.
- No significant differences in allele frequencies were observed based on tobacco exposure or cancer site.
Takeaway
The study looked at whether a specific gene change increases the risk of a type of throat cancer and found that it does not.
Methodology
The study examined genotypic frequencies in 163 cases of squamous cell carcinoma and 163 matched controls.
Participant Demographics
Participants included 163 cases with squamous cell carcinoma and 163 ethnically matched controls.
Statistical Information
P-Value
0.50
Statistical Significance
p=0.50
Digital Object Identifier (DOI)
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