Effects of Dexmedetomidine on Kidney Function During Heart Surgery
Author Information
Author(s): Kari Leino, Markku Hynynen, Jouko Jalonen, Markku Salmenperä, Harry Scheinin, Riku Aantaa
Primary Institution: Turku University Hospital
Hypothesis
Dexmedetomidine would improve kidney function in patients undergoing elective CABG during the first two postoperative days.
Conclusion
Use of intravenous dexmedetomidine did not alter renal function in this cohort of relatively low-risk elective CABG patients but was associated with an increase in urinary output.
Supporting Evidence
- The study included 87 randomized patients, with 66 evaluable for analysis.
- There was a mean 74% increase in urinary output with dexmedetomidine in the first 4 hours after catheter insertion.
- No significant between-group differences were recorded for any indices of renal function except for urinary output.
Takeaway
This study looked at whether a drug called dexmedetomidine helps the kidneys during heart surgery. It found that while it didn't help kidney function, it did make patients pee more.
Methodology
This was a double-blind, randomized, parallel-group study comparing dexmedetomidine with placebo in patients undergoing elective CABG.
Potential Biases
There may have been interindividual differences in plasma concentrations of dexmedetomidine due to not measuring true individual levels.
Limitations
The study was prematurely terminated due to slow recruitment and included patients at relatively low risk of AKI.
Participant Demographics
Patients were adults (aged > 21 years) with normal renal function scheduled for elective CABG.
Statistical Information
P-Value
p < 0.001
Confidence Interval
from -16.80 to 7.86 ml · min-1 · 1.73 m-2
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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