Biomedical Benefits of Nitraria retusa Extract
Author Information
Author(s): Khowdiary Manal M., Alatawi Zinab, Alhowiti Amirah, Amin Mohamed A., Daghistani Hussam, Albaqami Faisal Miqad K., Abdel-Rahman Mohamed Ali, Ghareeb Ahmed, Shaer Nehad A., Shawky Ahmed M., Fouda Amr, Lamponi Stefania, Kiss Rita, Pallag Annamária
Primary Institution: Umm Al-Qura University, Makkah, Saudi Arabia
Hypothesis
The study aims to investigate the phytochemical composition and biological activities of Nitraria retusa extract.
Conclusion
Nitraria retusa extract shows strong antioxidant, selective cytotoxicity against cancer cells, and broad-spectrum antimicrobial activity.
Supporting Evidence
- Nitraria retusa extract has a high concentration of bioactive compounds like ellagic acid and catechin.
- The extract showed significant antioxidant activity, outperforming ascorbic acid.
- It demonstrated selective cytotoxicity against cancer cell lines while sparing normal cells.
- The extract exhibited broad-spectrum antimicrobial activity, particularly against E. coli and Penicillium glabrum.
- Further research is needed to explore the extract's potential therapeutic applications.
Takeaway
Nitraria retusa is a plant that can help fight cancer and infections because it has special chemicals that protect our cells.
Methodology
The study used HPLC analysis, DPPH assays for antioxidant activity, MTT assays for cytotoxicity, and agar well diffusion for antimicrobial testing.
Limitations
Further in vivo studies are needed to confirm the safety and efficacy of the extract.
Statistical Information
P-Value
68.2 ± 4.2 μg/mL for α-amylase inhibition
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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