Splitting the BLOSUM Score into Numbers of Biological Significance
2007
Understanding the BLOSUM Score
publication
Author Information
Author(s): Fabris Francesco, Sgarro Andrea, Tossi Alessandro
Primary Institution: Università degli Studi di Trieste
Hypothesis
Can the BLOSUM score be split into components that have biological significance?
Conclusion
The study provides a method to analyze the BLOSUM score, enhancing the understanding of protein sequence comparisons.
Supporting Evidence
- The BLOSUM score can be divided into three components for better analysis.
- This method improves the identification of weakly related protein sequences.
- The BLOSpectrum can help choose the best scoring matrix for protein comparisons.
Takeaway
This study helps scientists understand how to compare protein sequences better by breaking down a scoring system into meaningful parts.
Methodology
Mathematical tools from Shannon information theory were used to analyze the BLOSUM score.
Digital Object Identifier (DOI)
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