Prognostic Significance of MIB1 in Breast Cancer
Author Information
Author(s): Imamura H, Haga S, Shimizu T, Watanabe O, Kajiwara T, Aiba M
Primary Institution: Tokyo Women's Medical College Daini Hospital
Hypothesis
The study investigates the prognostic significance of MIB1-determined proliferative activities in intraductal components and invasive foci associated with invasive ductal breast carcinoma.
Conclusion
MIB1-determined proliferative activity of intraductal components is a significant prognostic determinant of invasive ductal breast carcinoma.
Supporting Evidence
- MLI-DCIS correlated closely with MLI-INV (r = 0.710).
- Both MLI-DCIS and MLI-INV were related to oestrogen receptor status.
- MLI-DCIS and MLI-INV were significant in univariate disease-free survival analysis.
Takeaway
This study looked at how fast cancer cells are growing in certain parts of breast cancer and found that it can help predict how the disease will progress.
Methodology
Proliferative activity was measured as the number of MIB1-positive nuclei per 1000 cancer cells in the most active areas of intraductal components and invasive foci.
Statistical Information
P-Value
P<0.0001
Confidence Interval
0.623–0.780
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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