Psychometric Properties of Well-being Measures in Growth Hormone Deficiency
Author Information
Author(s): McMillan Carolyn V, Bradley Clare, Gibney James, Russell-Jones David L, Sönksen Peter H
Primary Institution: Royal Holloway, University of London
Hypothesis
The study evaluates the psychometric properties of the General Well-being Index and the Well-being Questionnaire in adults with growth hormone deficiency.
Conclusion
The W-BQ12 is recommended over the GWBI for measuring well-being in adults with growth hormone deficiency due to its shorter length, useful subscales, and greater sensitivity to change.
Supporting Evidence
- Both questionnaires had very high completion rates, indicating good acceptability to respondents.
- The W-BQ12 showed greater sensitivity to change compared to the GWBI in the GH-Withdrawal study.
- Men reported significantly better overall well-being than women in both questionnaires.
- Significant correlations were found between duration of GH treatment and well-being scores.
Takeaway
This study looked at how well two questionnaires measure happiness in adults who don't have enough growth hormone. One questionnaire is better because it's shorter and shows changes in well-being more clearly.
Methodology
The study involved a cross-sectional survey and a randomized placebo-controlled trial assessing the reliability and validity of two well-being questionnaires.
Potential Biases
Potential bias due to the selection of symptomatic patients for GH treatment.
Limitations
The small sample size in the GH-Withdrawal study limited the power of the analysis.
Participant Demographics
Participants included 157 adults with growth hormone deficiency, aged 18-70, with a mix of childhood and adult onset of GHD.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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