Genetic Study of Japanese Encephalitis Virus Genotype II Strains
Author Information
Author(s): Amy J. Schuh, Robert B. Tesh, Alan D. T. Barrett
Primary Institution: University of Texas Medical Branch
Hypothesis
What are the genetic variations and phylogenetic relationships among Japanese encephalitis virus genotype II strains isolated from 1951 to 1978?
Conclusion
The study found that genotype II strains of the Japanese encephalitis virus are genetically similar to genotype I strains but are epidemiologically distinct.
Supporting Evidence
- Genotype II strains were found to be most similar to genotype I strains based on nucleotide and amino acid composition.
- Selection analyses indicated that the strains are under predominantly purifying selection.
- Evidence of positive selection was detected at aa 24 of the NS4B protein.
Takeaway
Scientists looked at some old viruses that cause Japanese encephalitis to see how they are related to each other and found that they are similar but belong to different groups.
Methodology
The study sequenced the ORF of three JEV strains and compared them with other strains using phylogenetic analysis.
Limitations
The study is limited by the small number of genotype II strains available for analysis.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website