Responding to blood lead levels < 10 μg/dL
2008

Blood Lead Levels in Children

publication Evidence: high

Author Information

Author(s): Rothenberg Stephen J.

Primary Institution: Centro de Investigación y de Estudios, Avanzados Instituto Politécnico Nacional, Mérida, Yucatán, México

Hypothesis

Increased national IQ from decreased child blood lead levels in the United States from the late 1970s to 2002 based on the nonlinear relationship.

Conclusion

Scientific evidence supports revising the standard for blood lead levels to well below 5 μg/dL to better protect children.

Supporting Evidence

  • Lead inhibits δ-aminolevulinic acid dehydratase activity in humans.
  • Lead inhibits peak current amplitude of acetylcholine-induced currents in cultured rat hippocampal neurons.
  • Increasing gestational lead resulted in increasing incomplete responses during acquisition of a fixed-ratio operant task in monkeys.
  • Evidence today points to risk for developmental damage down to the lowest blood lead levels explored in prospective studies.

Takeaway

The study suggests that lower blood lead levels are better for children's health and that current standards may not be protecting them enough.

Potential Biases

The authors may have biases due to their stance on the CDC's blood lead level standards.

Limitations

The editorial lacks substantial evidence to support its claims and ignores relevant studies.

Digital Object Identifier (DOI)

10.1289/ehp.11636

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