Optimal Indications for Endocrine Therapy in Breast Cancer
Author Information
Author(s): Horii R, Akiyama F, Ito Y, Iwase T
Primary Institution: The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan
Hypothesis
Is the St Gallen algorithm valid for Japanese breast cancer patients and what are the optimal indications for endocrine monotherapy as adjuvant treatment?
Conclusion
The St Gallen algorithm is valid for classifying Japanese breast cancer patients, and endocrine monotherapy may be sufficient for intermediate-risk patients with specific conditions.
Supporting Evidence
- Endocrine responsiveness was classified into responsive, uncertain, and non-responsive categories.
- 10-year recurrence-free survival rates varied significantly among different risk categories.
- Intermediate-risk patients with negative lymph node metastasis and one risk factor had the best outcomes.
Takeaway
This study looked at how well a treatment guideline works for Japanese women with breast cancer and found that some patients might do just fine with a simpler treatment.
Methodology
The study assessed 436 invasive breast cancer patients who underwent surgery and adjuvant tamoxifen therapy, evaluating their endocrine responsiveness and recurrence risk according to the St Gallen algorithm.
Limitations
The study excluded certain patient groups, which may limit the generalizability of the findings.
Participant Demographics
Mean age was 55 years, with 35% premenopausal and 65% postmenopausal patients.
Statistical Information
P-Value
p=0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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