Bioactivity Evaluation and Phytochemical Characterization of Euonymus alatus Leaf Extract
Author Information
Author(s): Yoon Won-Joo, Min Hye-Ji, Cho Hyun-Dong, Kim Hwi-Gon, Park Wool-Lim, Kim Du-Hyun, Tachibana Hirofumi, Seo Kwon-Il, Marverti Gaetano, Lu Jun
Primary Institution: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
Hypothesis
The study investigates the antioxidant, antidiabetic, anticancer, and life-prolonging effects of Euonymus alatus leaf extract.
Conclusion
E. alatus leaf ethanol extract has potential as an antioxidant, antidiabetic, anticancer, and life-prolonging agent.
Supporting Evidence
- The ethanol extract contained the highest levels of polyphenols and flavonoids compared to other extracts.
- The ethanol extract exhibited superior antioxidant activities.
- The ethanol extract selectively inhibited the proliferation of breast and prostate cancer cells.
- Treatment with the extract extended the lifespan of tumor-bearing mice to 50 days.
Takeaway
This study found that a plant called Euonymus alatus can help fight diseases like cancer and diabetes and may help people live longer.
Methodology
The study used in vitro and in vivo models to evaluate the effects of E. alatus leaf extracts prepared with different solvents.
Limitations
The study did not compare the efficacy of E. alatus extracts using different solvents comprehensively.
Participant Demographics
Four-week-old male ICR mice were used in the in vivo experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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