Effects of Bryonia alba on Immune System in Mice with Chemotherapy-Induced Immunosuppression
Author Information
Author(s): Saka Vara Prasad, Kumar Godlaveti Vijay Narasimha, Goswami Abanti, Sanapalli Bharat Kumar Reddy, Gupta Pankaj, Verma Digvijay, Kaushik Subhash
Primary Institution: Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata, India
Hypothesis
Can Bryonia alba improve immune function in mice with cyclophosphamide-induced immunosuppression?
Conclusion
Bryonia alba can enhance immune parameters in mice suffering from immunosuppression due to chemotherapy.
Supporting Evidence
- Treatment with Bryonia alba improved RBC, WBC, and Hb levels in immunosuppressed mice.
- BA treatment increased serum levels of key immune cytokines IL-2, IL-4, TNF-α, and IFN-γ.
- Histopathological analysis showed preserved spleen architecture in BA-treated mice.
Takeaway
This study shows that a plant called Bryonia alba can help boost the immune system in mice that are sick from chemotherapy.
Methodology
The study involved administering different potencies of Bryonia alba to BALB/c mice that were immunosuppressed using cyclophosphamide, followed by various immune function assessments.
Limitations
The study used a mouse model, which may not fully replicate human immune responses.
Participant Demographics
70 BALB/c mice (35 males and 35 females)
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website