Evolution of Cancer
1990
Evolution of Cancer
publication
Author Information
Author(s): S. Okuyama, H. Mishina
Primary Institution: University of Tokyo
Hypothesis
Cancer represents a process of evolution in reverse, termed 'devolution'.
Conclusion
The authors struggle to formulate a clear treatment strategy based on their concepts of evolution and devolution of cancer.
Supporting Evidence
- Fanconi's anaemia is cited as an evolutionary experiment of nature on carcinogenesis.
- The early manifestation of non-malignancies and later occurrence of epithelial tumours supports the evolution theory.
- Cancer incidence in Japan after the atomic bomb explosions supports the evolution theory.
- Parallel evolution of biology with physicochemical alterations on earth supports the evolution theory.
Takeaway
The book suggests that cancer is like going backward in evolution, but it doesn't give clear advice on how to treat it.
Methodology
The authors use a variety of biological data to support their theories.
Limitations
The book is difficult to read and lacks a clear treatment strategy.
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