Study of Simple Sequence Proteins in Prokaryotes
Author Information
Author(s): Subramanyam Mekapati Bala, Gnanamani Muthiah, Ramachandran Srinivasan
Primary Institution: Institute of Genomics and Integrative Biology, Delhi, India
Hypothesis
The study investigates the structural and functional features of Simple Sequence Proteins (SSPs) in prokaryotic proteomes.
Conclusion
SSPs are a minority in prokaryotic proteomes but their growth and pattern are influenced by genomic base compositional bias and duplications.
Supporting Evidence
- SSPs grow with proteome size across various species.
- The proportion of SSPs is influenced by genomic base compositional bias.
- Amino acids in SSPs are preferred based on low biosynthetic cost.
- SSPs preferentially associate with cell surface and transport functions.
Takeaway
Simple Sequence Proteins are special types of proteins that are not very common, but they grow in number as the size of the organism's proteins increases.
Methodology
The study analyzed complete proteome sequences of 249 prokaryotes to identify and classify Simple Sequence Proteins.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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