Variation in G + C Composition and Codon Usage Bias in Bacteria
Author Information
Author(s): Haruo Suzuki, Rintaro Saito, Masaru Tomita
Primary Institution: Institute for Advanced Biosciences, Keio University
Hypothesis
The correlation of G + C composition with synonymous codon usage bias varies among different bacterial genomes.
Conclusion
The strength of the correlation between G + C composition and synonymous codon usage bias varies widely among bacterial genomes.
Supporting Evidence
- The correlation coefficient of G + C composition with synonymous codon usage bias ranged from 0.07 to 0.95 among bacterial genomes.
- Previous analyses suggested that the relationship between G + C composition and codon usage bias is independent of species, which this study contradicts.
Takeaway
This study looked at how the amount of certain DNA letters in bacteria relates to how they use different codes to make proteins, and found that this relationship is different for different bacteria.
Methodology
Shannon entropy was used to measure the degree of G + C bias and synonymous codon usage bias in bacterial genomes.
Limitations
The study may not account for all factors influencing codon usage bias across different species.
Digital Object Identifier (DOI)
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