Mutations of the β- and γ-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas
2001
Mutations of β- and γ-catenin genes in human cancers
Sample size: 134
publication
Evidence: low
Author Information
Author(s): Ueda M, Gemmill R M, West J, Winn R, Sugita M, Tanaka N, Ueki M, Drabkin H A
Primary Institution: Osaka Medical College
Hypothesis
Are mutations of the β- and γ-catenin genes common in various human carcinomas?
Conclusion
Mutations of β- and γ-catenins are infrequent in human lung, breast, kidney, cervical, and ovarian carcinomas.
Supporting Evidence
- 93 lung, 9 breast, 6 kidney, 19 cervical, and 7 ovarian carcinoma cell lines were examined for mutations.
- Mutational analysis confirmed a deletion in lung mesothelioma and a silent mutation in cervical adenocarcinoma.
- Missense and silent mutations were found in specific lung carcinoma cell lines.
Takeaway
The study looked for changes in certain genes in different types of cancer and found that these changes are not very common.
Methodology
PCR and single-strand conformational polymorphism analysis were used to examine various carcinoma cell lines for mutations.
Digital Object Identifier (DOI)
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