ISL1 Promotes Pancreatic Islet Cell Proliferation
2011
ISL1 Promotes Pancreatic Islet Cell Proliferation
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Guo Ting Wang, Weiping Zhang, Hui Liu, Yinan Chen, Ping Ma, Kangtao Zhou, Chunyan Zhou
Primary Institution: Peking University, Beijing, China
Hypothesis
ISL1 plays a role in maintaining the balance of islet cell renewal and cell loss.
Conclusion
ISL1 promotes adult pancreatic islet cell proliferation and likely does so by activating c-Myc and CyclinD1 transcription.
Supporting Evidence
- ISL1 expression was up-regulated in pancreatic cells undergoing glucose oxidase stimulation.
- Knockdown of ISL1 increased apoptosis in HIT-T15 pancreatic islet cells.
- ISL1 overexpression increased the proportion of cells in G2/M and S phases.
Takeaway
ISL1 helps pancreatic cells grow and stay alive, especially when they are under stress from sugar.
Methodology
The study used HIT-T15 and primary adult islet cells to analyze the effects of ISL1 on cell proliferation and apoptosis.
Participant Demographics
Adult Sprague-Dawley rats and various diabetes mouse models.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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