Er81 is a downstream target of Pax6 in cortical progenitors
2008
Pax6 Controls Er81 Expression in Cortical Progenitors
publication
Evidence: moderate
Author Information
Author(s): Tuoc Tran Cong, Stoykova Anastassia
Primary Institution: Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany
Hypothesis
Is Er81 a direct target of the transcription factor Pax6 in cortical progenitors?
Conclusion
The study concludes that Pax6 regulates the expression of Er81, which is important for the specification of layer 5 projection neurons in the cortex.
Supporting Evidence
- Pax6 is essential for the expression of Er81 in cortical progenitors.
- The study identified a specific binding site for Pax6 in the Er81 promoter.
- Pax6 overexpression leads to increased Er81 promoter activity in cell cultures.
Takeaway
Pax6 helps decide what type of neurons develop in the brain by controlling another protein called Er81.
Methodology
The study involved analyzing the regulatory function of the Er81 promoter and conducting experiments in cell cultures and transgenic mice.
Digital Object Identifier (DOI)
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