Vesnarinone and glucocorticoids cooperatively induce G1 arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
1999
Vesnarinone and glucocorticoids in lung cancer treatment
publication
Author Information
Author(s): Honma Y, Yamamoto-Yamaguchi Y, Kanatani Y
Primary Institution: Department of Chemotherapy, Saitama Cancer Center Research Institute
Hypothesis
Vesnarinone combined with glucocorticoids will enhance anti-tumor effects on lung carcinoma cells.
Conclusion
The combination of vesnarinone and glucocorticoids effectively inhibits the growth of lung carcinoma cells.
Supporting Evidence
- Vesnarinone inhibited the growth of several human non-small cell lung carcinoma cell lines.
- The anti-proliferative effects were enhanced by combination with glucocorticoids.
- Simultaneous treatment with vesnarinone and dexamethasone was the most effective.
- Dexamethasone induced morphological changes in EBC-1 cells.
- The treatment arrested the growth of the cells at the G1 phase.
Takeaway
Vesnarinone, when used with glucocorticoids, can help stop lung cancer cells from growing.
Methodology
The study involved in vitro and in vivo experiments on human non-small cell lung carcinoma cell lines.
Digital Object Identifier (DOI)
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