EXCHANGE REACTIONS BETWEEN ALBUMIN-GOLD(1)-TRIETHYLPHOSPHINE AND Me3PAuCI OR iPr3PAuCI STUDIED BY 3p NMR SPECTROSCOPY
Exchange Reactions of Albumin-Gold Complexes
publication
Author Information
Author(s): Anvarhusein A. Isab, C. Frank Shaw III, Amalia Munoz
Primary Institution: University of Wisconsin-Milwaukee
Hypothesis
The study investigates how different gold complexes exchange with albumin in vitro.
Conclusion
The study found that both Me3PAu+ and iPr3PAu+ can replace Et3PAu+ in the albumin-gold complex.
Supporting Evidence
- The AIbSAuPEt3 complex was prepared in vitro by reacting albumin with aumnofin.
- Et3PAu+ was found to be labile to exchange in the presence of Me3PAuCI and iPr3PAuCI.
- The study demonstrates that Et3PAu+ can be transferred to form a bis complex with albumin.
Takeaway
The researchers looked at how gold compounds interact with a protein called albumin, and found that two different gold compounds can swap places with another one in the protein.
Methodology
The study used 31p NMR spectroscopy to observe the exchange reactions of gold complexes with albumin.
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