Presence of galactosylated core fucose on N-glycans in the planaria Dugesia japonica
2011
Study of N-glycans in Planaria
publication
Evidence: moderate
Author Information
Author(s): Katharina Paschinger, Ebrahim Razzazi-Fazeli, Kiyoshi Furukawa, Iain B. H. Wilson
Primary Institution: Universität für Bodenkultur
Hypothesis
Glycan–lectin interactions may play a role in the developmental processes of planaria.
Conclusion
The study reveals the presence of galactosylated core fucose on N-glycans in the planaria Dugesia japonica, indicating that this modification is not limited to molluscs and nematodes.
Supporting Evidence
- The study is the first to report these types of structures in a platyhelminth.
- Galβ1,4Fuc modification is more widely present than previously thought.
- Planaria may have the full complement of mannosyltransferases required for N-glycosylation.
Takeaway
Scientists looked at the sugars on planaria and found some new types that help us understand how these creatures might heal and grow.
Methodology
The N-glycans were analyzed using peptide:N-glycosidase A, HPLC, and mass spectrometry.
Digital Object Identifier (DOI)
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