RADA Peptide Extends Survival in Hamsters Infected with Scrapie
Author Information
Author(s): Robert Hnasko, Cathrin E. Bruederle, Joseph El Khoury
Primary Institution: United States Department of Agriculture (USDA), Agricultural Research Service (ARS), Pacific West Area (PWA), Western Regional Research Center- Foodborne Contaminants Research Unit (WRRC-FCR), Albany, California, United States of America
Hypothesis
Can a self-assembling RADA-peptide disrupt prion accumulation and extend survival in hamsters infected with Scrapie?
Conclusion
The RADA-peptide significantly delayed disease onset and increased survival in hamsters infected with Scrapie.
Supporting Evidence
- Hamsters inoculated with RADA and Scrapie survived significantly longer than those with Scrapie alone.
- The mean survival time for RADA-treated hamsters was 114 days compared to 78 days for controls.
- RADA treatment resulted in delayed clinical symptoms and reduced prion accumulation at early time points.
Takeaway
Researchers found that a special peptide can help hamsters live longer after getting a brain disease caused by prions.
Methodology
Hamsters were inoculated with Scrapie brain homogenate combined with RADA-peptide and monitored for survival and clinical symptoms.
Limitations
The study was conducted in hamsters, and results may not directly translate to humans.
Participant Demographics
Female Syrian Golden hamsters, 4 weeks old.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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