Free Radical Detoxifying Systems in Human Colorectal Cancer
Author Information
Author(s): C.E.J. Hoffman, N.R. Webster, P.A. Wiggins, E.M. Chisholm, G.R. Giles, S.H. Leveson
Primary Institution: University Department of Surgery, St James's University Hospital, Leeds
Hypothesis
Are there abnormalities in Cu/Zn-SOD, Mn-SOD, and other detoxifying enzymes in human colorectal adenocarcinomas?
Conclusion
The study found significant differences in the activities of Cu/Zn-SOD and Mn-SOD between tumor and normal mucosa, as well as a reduction in catalase activity in tumors.
Supporting Evidence
- The study confirmed previous findings of reduced superoxide dismutase activity in human colorectal tumors.
- Catalase activity was also significantly lower in tumor samples compared to normal mucosa.
- No significant differences were found in glutathione peroxidase or TBA reactive compounds.
Takeaway
The study looked at how well certain enzymes that fight harmful substances work in cancerous and normal tissue from the same patients, finding that the cancerous tissue had lower levels of some of these enzymes.
Methodology
The study measured activities of superoxide dismutase and its components, catalase, and glutathione peroxidase in tumor and normal mucosa samples from patients undergoing colonic resection.
Limitations
The study did not investigate the influence of other factors such as the site or degree of differentiation of the tumor on enzyme levels.
Participant Demographics
12 male and 11 female patients with colorectal cancer.
Statistical Information
P-Value
p<0.01 for Cu/Zn-SOD and Mn-SOD, p<0.01 for catalase
Statistical Significance
p<0.01
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